Bilirubin prevents acute DSS-induced colitis by inhibiting leukocyte 4 infiltration and suppressing up-regulation of inducible nitric oxide
نویسندگان
چکیده
3 Bilirubin prevents acute DSS-induced colitis by inhibiting leukocyte 4 infiltration and suppressing up-regulation of inducible nitric oxide 5 synthase 6 7 8 9 Stephen D. Zucker*, Megan E. Vogel, Tammy L. Kindel, Darcey L.H. Smith, Gila Idelman, Uri 10 Avissar, Ganesh Kakarlapudi, and Michelle E. Masnovi 11 12 13 Division of Digestive Diseases, University of Cincinnati, Cincinnati, OH 45267-0595 14 15 16 17 18 19 20 21 Date: August 14, 2015 22 23 24 Running Head: Bilirubin prevents DSS-induced colitis 25 26 27 28 29 30 31 32 33 * To whom correspondence should be addressed: 34 35 Stephen D. Zucker, M.D. 36 Division of Digestive Diseases 37 University of Cincinnati 38 231 Albert B. Sabin Way, M.L. 0595 39 Cincinnati, OH 45267-0595 40 Tel: (513) 558-5244 41 Fax: (513) 558-1744 42 Email: [email protected] 43 Articles in PresS. Am J Physiol Gastrointest Liver Physiol (September 17, 2015). doi:10.1152/ajpgi.00149.2014
منابع مشابه
Bilirubin prevents acute DSS-induced colitis by inhibiting leukocyte infiltration and suppressing upregulation of inducible nitric oxide synthase.
Bilirubin is thought to exert anti-inflammatory effects by inhibiting vascular cell adhesion molecule-1 (VCAM-1)-dependent leukocyte migration and by suppressing the expression of inducible nitric oxide synthase (iNOS). As VCAM-1 and iNOS are important mediators of tissue injury in the dextran sodium sulfate (DSS) murine model of inflammatory colitis, we examined whether bilirubin prevents colo...
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